Teach you how to analyze the power of the sweeper
A good sweeping vehicle mainly through its sweeping function, climbing ability, as well as the use of time and power function, the power of the sweeper is usually the speed of the sweeper, the ability to climb the slope (the maximum climbing grade) and the maximum speed These items are used as evaluation indicators. Below, sweeping car manufacturers teach you three points to analyze the power of sweeping cars:
First, the capacity of the Dongfeng Road Sweeper uphill is assessed using the maximum grade. The maximum climbing grade refers to the maximum road gradient that can be overcome when the sweeping vehicle is fully loaded with the lowest gear of the transmission on a hard road.
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Secondly, the maximum speed of the Dongfeng Sweeper is the maximum speed at which the sweeping vehicle is fully loaded on a well-grounded road surface. Obviously, when the Dongfeng engine's throttle is fully open or the injection pump plunger is turned to the maximum fuel supply position, the transmission should be linked to the highest grade;
Thirdly, the acceleration of the sanitation sweeper refers to the acceleration acceleration a, acceleration time t, and acceleration stroke s in the accelerative process of the ability of the sweeper to rapidly increase the running speed under various conditions of use. The larger the a, t The shorter the s, the faster the acceleration. The higher the average speed, the better the power. The acceleration capability of the Dongfeng Sweeper has a great influence on the average travel speed of the sweeper.
Finally, the sweeping vehicle manufacturers remind everyone that it is best not to exceed the maximum power index of the sweeper in various situations when using a sweeper, otherwise it will have a certain impact on the service life of the sweeper.
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Apalutamide (INN) (developmental code name ARN-509, also JNJ-56021927) is a non-steroidal antiandrogen that is under development for the treatment of prostate cancer. It is similar to enzalutamide both structurally and pharmacologically, acting as a selective competitive antagonist of the androgen receptor (AR), but shows some advantages, including greater potency and reduced central nervous system permeation. Apalutamide binds weakly to the GABAA receptor similarly to enzalutamide, but due to its relatively lower central concentrations, may have a lower risk of seizures in comparison.
The drug has been found to be effective and well-tolerated in clinical trials thus far, with the most common side effects reported including fatigue, nausea, abdominal pain, and diarrhea.Apalutamide is currently in phase III clinical trials for castration-resistant prostate cancer.
Recently, the acquired F876L mutation of the AR identified in advanced prostate cancer cells was found to confer resistance to both enzalutamide and apalutamide. A newer antiandrogen, darolutamide (ODM-201), is not affected by this mutation, nor has it been found to be affected by any other tested/well-known AR mutations.; Apalutamide may be effective in a subset of prostate cancer patients with acquired resistance to abiraterone acetate.
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